Determinants of local responsiveness of FMNCS in mainland China

Recent regulations, associated with China’s accession to the World Trade Organisation (WTO), specifically Decree 113 and Decree 114, have largely changed the situation for foreign multinational construction companies (FMNCs) operating in mainland China. A field investigation has identified that local responsiveness is critical for FMNCs to survive and develop in the complicated and uncertain Chinese construction industry. Government policy, China-specific construction industrial factors and increasing competition intensity imposed by local competitors are recognized as the major determinants driving local responsiveness of FMNCs. This study has also examined that localisation of internal resources, establishment of local networks and cooperation or strategic alliances with local contractors and design institutes are the key local adaptation strategies for FMNCs operating in mainland China

The General Primordial Cosmic Perturbation

We consider the most general primordial cosmological perturbation in a universe filled with photons, baryons, neutrinos, and a hypothetical cold dark matter (CDM) component within the framework of linearized perturbation theory. We give a careful discussion of the different allowed modes, distinguishing modes which are regular at early times, singular at early times, or pure gauge. As well as the familiar growing and decaying adiabatic modes and the baryonic and CDM isocurvature modes we identify two {\it neutrino isocurvature} modes which do not seem to have been discussed before. In the first, the ratio of neutrinos to photons varies spatially but the net density perturbation vanishes. In the second the photon-baryon plasma and the neutrino fluid have a spatially varying relative bulk velocity, balanced so that the net momentum density vanishes. Possible mechanisms which could generate the two neutrino isocurvature modes are discussed. If one allows the most general regular primordial perturbation, all quadratic correlators of observables such as the microwave background anisotropy and matter perturbations are completely determined by a $5\times 5,$ real, symmetric matrix-valued function of co-moving wavenumber. In a companion paper we examine prospects for detecting or constraining the amplitudes of the most general allowed regular perturbations using present and future CMB data.Comment: 18 pages, 2 Postscript figures, uses revtex. Revised 2-2000 Minor errors corrected and some references adde

Constraining Isocurvature Perturbations with CMB Polarization

The role of cosmic microwave background (CMB) polarisation data in constraining the presence of primordial isocurvature modes is examined. While the MAP satellite mission will be unable to simultaneously constrain isocurvature modes and cosmological parameters, the PLANCK mission will be able to set strong limits on the presence of isocurvature modes if it makes a precise measurement of the CMB polarisation sky. We find that if we allow for the possible presence of isocurvature modes, the recently obtained BOOMERANG measurement of the curvature of the universe fails. However, a comparably sensitive polarisation measurement on the same angular scales will permit a determination of the curvature of the universe without the prior assumption of adiabaticity.Comment: 4pages, Latex with four eps figures. (Revised 18 Dec 2000. Minor typos corrected

Features: Community engagement for biobanking research: perspectives from Africa

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Data mining and biological sample exportation from South Africa: a new wave of bioexploitation under the guise of clinical care?

Discovery Health, one of the leading healthcare funders in South Africa (SA), will offer genetic testing to its members for USD250 (approximately ZAR3 400) per test from 2016. On the surface, this appears to be innovative and futuristic. However, a deeper look at this announcement reveals considerable problems in the exportation of biological samples and data out of SA, and brings into sharp focus the lack of protection in place for potential donors. In return for a reduced-cost genetic test, which will nevertheless be billed to a member’s savings plan, data from the patient’s results and probably the sample itself Author: OK? will be sent to the USA for storage, research purposes and possible commercialisation, Author ‘commercial use’? with no further benefit for the patient. This development has demonstrated the need for more stringent protection of the movement of biological samples and data out of SA, particularly with reference to consenting procedures, material transfer agreements, and the export of biological data themselves

The implications of Methylphenidate use by healthy medical students and doctors in South Africa

Background: The use of medical stimulants to sustain attention, augment memory and enhance intellectual capacity is increasing in society. The use of Methylphenidate for cognitive enhancement is a subject that has received much attention in the literature and academic circles in recent times globally. Medical doctors and medical students appear to be equally involved in the off-label use of Methylphenidate. This presents a potential harm to society and the individual as the long-term side effect profile of this medication is unknown. Discussion: The implication of the use of Methylphenidate by medical students and doctors has not been fully explored. This article considers the impact of this use on the traditional role of medicine, society, the patient and suggests a way forward. We discuss the salient philosophy surrounding the use of cognitive enhancement. We query whether there are cognitive benefits to the use of Methylphenidate in healthy students and doctors and whether these benefits would outweigh the risks in taking the medication. Could these benefits lead to tangible outcomes for society and could the off label-use of Methylphenidate potentially undermine the medical profession and the treatment of patients? If cognitive benefits are proven then doctors may be coerced explicitly or implicitly to use the drug which may undermine their autonomy. The increased appeal of cognitive enhancement challenges the traditional role of medicine in society, and calls into question the role of a virtuous life as a contributing factor for achievement. In countries with vast economic disparity such as South Africa an enhancement of personal utility that can be bought may lead to greater inequities. Summary: Under the status quo the distribution of methylphenidate is unjust. Regulatory governmental policy must seek to remedy this while minimising the potential for competitive advantage for the enhanced. Public debate on the use of cognitive enhancement is long overdue and must be stimulated. The use of Methylphenidate for cognitive enhancement is philosophically defendable if long-term research can prove that the risks are negligible and the outcomes tangible

Prevalence of anaemia in pregnancy in a regional health facility in South Africa

Background. Anaemia is a major global health problem affecting an estimated 42% of pregnant women worldwide. There is a paucity of South African (SA) data on anaemia in pregnancy, despite the fact that parasitic infections are endemic and the nutritional status of sections of the population is poor.Objective. To determine the prevalence of anaemia among antenatal attendees in a regional hospital in Durban, SA.Methods. This was a cross-sectional prospective study in a regional health facility in an urban setting serving a population of low socioeconomic status. Venous blood samples to perform a full blood count were obtained from antenatal attendees at their first clinic visit.Results. Two thousand pregnant women were studied; the mean (standard deviation) age and gestational age at booking was 27.6 (7.6) years and 21.7 (7.1) weeks, respectively. Eight hundred and fifty-four (42.7%) were anaemic (haemoglobin (Hb) levels <11 g/dL). The majority (81.4%) were mildly anaemic. There were five (0.6%) cases of severe anaemia (Hb <7 g/dL). The prevalence of anaemia was significantly higher in HIV-positive compared with HIV-negative pregnant women (71.3% v. 28.7%; p<0.0001). The common morphology was normochromic normocytic (n=588, 68.9%).Conclusion. The prevalence of anaemia was 42.7%. In the majority (81.4%) the anaemia was mild and normocytic and normochromic (68.9%). Anaemia is a common problem among antenatal attendees in an SA urban population